Frequency
Infertility is defined as failure to conceive before the age of 35 despite 1 year of regular sexual intercourse. If after 4 months of sexual intercourse above the age of 35 years, the test is started. Infertility is on the increase nowadays, with 30-40% of cases being female, 20-30% male and 40% of cases being both.
Causes
1. Hormonal abnormalities are a large group of causes of female infertility.
The reason in these cases is that ovulation does not occur and fertilisation is not possible. The fault is looked for in our endocrine glands – hypothalamus, pituitary, ovaries, thyroid, adrenal cortex. Defects in these organs can be found by blood tests and imaging (Skull MRI, Pelvic CT). The solution can be found with medication or surgery (ovarian cyst removal). A specific form of this group is Polycystic Ovary Syndrome (PCOS). In this disease, the woman’s body produces too much androgen hormone, thus inhibiting ovulation. It is a complex endocrine disorder because, in addition to the failure to ovulate, there is also a disturbance in sugar metabolism. These patients are often latent diabetics, which can only be detected by exercise glucose testing. The disease can be treated with hormone therapy and/or surgery.
2. Another large group of female infertility is mechanical abnormalities.
These include congenital abnormalities of the vagina, uterus and fallopian tubes (insufficient development of the organs or deformities of the shape), which can usually be treated surgically. The most common of the acquired abnormalities is an obstruction of the fallopian tubes, which may be due to a history of inflammation, a previous ectopic pregnancy or endometriosis. This can be tested in an outpatient clinic by filling the uterine cavity with a special fluid and observing the outflow of fluid through the fallopian tubes. This test, called HyCoSy, is painless and does not involve any radiation exposure or anaesthetic risk.
Another common cause, which also causes abdominal pain and abnormal bleeding in middle-aged women, is a benign tumour of the uterus, called myoma. The location, size and number of myomas determine the type of surgical solution.
Previously, medication was an option, but has been suspended for the time being due to side effects. In all cases, the aim of the operation is to preserve the uterus and form a regular uterine space. From hysterectomy to laparoscopic myoma removal to complex hysterectomy with open surgery, any type of surgery is available. Our aim is to achieve a uterus suitable for embryo capture and expulsion.
Testing of the male partner is also extremely important, as we cannot perform interventional tests on women until we have ruled out infertility in men. This involves an examination of the external genitalia and a test of the semen. For example, the amount of semen ejaculated during an ejaculation, its pH, the number of sperm cells present, its shape and the number of motile cells are important.
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